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Question: In one signaling pathway initiated by a signaling molecule binding to its receptor tyrosine kinas…

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In one signaling pathway initiated by a signaling molecule
binding to its receptor tyrosine kinase (RTK), the membrane lipid
PIP2 has one more phosphate added to it, producing
PI(3,4,5)P3. Proteins that bind to this triply
phosphorylated inositol head group have what feature in common?

They all stimulate an active G protein to hydrolyze GTP to
GDP.

They all contain either an SH2 domain or a PTB domain.

They all result in the opening of Ca2+ channels.

They all contain a PH domain.

They all contain an SH3 domain.

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