(3) You have decided to study E. coli replication and you isolate several mutant strains of E. coli, each of which displays one of the characteristics listed below. For each phenotype listed below, you hypothesize the factor of DNA replication that is most likely altered and thus causing the aberrant phenotype. What component do you hypothesize is altered when: 2. a) No initiation of synthesis occurs b) Newly synthesized DNA contains mutations (mismatched base pairs) c) Okasaki fragments accumulate and DNA synthesis is never completed.