ATP is an indirect product of the citric acid cycle

Acetyl CoA can increase the pool of citric acid cycle
intermediates

Fatty acids can increase the pool of citric acid cycle
intermediates

ADP inhibits α-ketoglutarate dehydrogenase

The pool of mitochondrial oxaloacetate can be increased by
pyruvate

All enzymes of the citric acid cycle are found soluble and free
in the mitochondrial matrix

NADH

H⁺

H₂O

FAD

The E1 subunit is phosphorylated by pyruvate dehydrogenase
kinase, and the catalytic activity of pyruvate dehydrogenase
decreases.

The last step of the pyruvate dehydrogenase reaction is blocked,
resulting in a decrease in activity.

The pyruvate dehydrogenase phosphatase-1 enzyme would increase,
resulting in pyruvate dehydrogenase activation at an accelerated
rate.

The pyruvate dehydrogenase kinase enzyme activity would
increase, resulting in an increase in pyruvate dehydrogenase
activity.