

Show ALL reasoning 1. Red-green color blindness is an X-linked trait. In a population genetic study, 1,000 people, 500 men and 500 women, were tested for this trait, and 35 men were found to be color blind. Use this information to compute the frequency of the color blindness allele and the wild-type allele in this population, and estimate the expected number of carrier females. 2. Among Arabs the frequencies of alleles determining the ABO blood type groups were estimated as IA -0.209, /B 0.129, /O -0.660. What are the expected ABO genotypic frequencies? 3. Hurler syndrome is an autosomal recessive disease caused by a deficiency of the enzyme alpha-L-iduronidase. Affected individuals are mentally retarded, have skeletal abnormalities, and short stature. The population incidence is about 1 in 90,000. Calculate the allelic and genotypic frequencies for the disease assuming Hardy-Weinberg equilibrium 4. Given the following genotypic frequencies ofAA = 0.39, Aa-0.56, and aa-005, is this population in Hardy-Weinberg equilibrium? Explain why the data does or does not satisfy the Hardy-Weinberg principle 5. The genotypic frequencies of the MN blood groups in various populations are shown below. Given this information, determine if the genotypic frequencies are in general agreement with the Hardy-Weinberg law. Population Genotype frequenc a. U.S. whites b. American Indians c. Australian Aborigines 0.29 0.60 0.04 MN 0.48 0.35 0.28 0.23 0.05 0.68 6. Human blood type is determined by three alleles A P. and P. The alleles and「are co- dominant to each other, and both are dominant to 1°. Within a large, randomly mating population (540,000 individuals), the frequencies for the blood type alleles are 0.3 for the IA allele; 0.6 for 1°, and 0.1 for the IB allele. a. Calculate the expected numbers of people in the population having each blood type A, B, AB, and O b. Determine the percentage of type B people that are heterozygotes (IBT°)





